It runs under MacOSX, Windows and Linux and I should say from the outset that this feels very much like a proper Mac OS X application not a UNIX port. LIGANDSCOUT 3.12 SERIAL NUMBER MAC OS Xįrom the installer to the standard Mac OS X keyboard short cuts this has the look and feel of a Mac application.Īfter installation, on first start you are prompted for the serial number and then you are presented with the LigandScout desktop. To review LigandScout I thought it might be useful to use the outstanding work by the DupontMerck group on HIV Protease (Lam, P.Y., Jadhav, P.K., Eyermann, C.J., Hodge, C.N., Ru, Y., Bacheler, L.T., Meek, J.L., Otto, M.J., Rayner, M.M., Wong, Y.N., et al. (1994) Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors. Science 263: 380-384).HIV protease is an Aspartyl Proteinase that is formed as dimer. It is well validated target, the enzyme is unique to HIV virus and is not present in humans. It has been shown that active HIV protease is required for viral infectivity and a mutant HIV provirus (Asp to Asn) was unable to infect MT-4 lymphoids (Proc. The C2-symmetric nature of the HIV protease homodimer provides a unique property of the enzyme that could be exploited in the drug design process. X-ray data revealed that both the N- and C-termini of the asymmetric substrates and the inhibitors bind to identical subsites. LIGANDSCOUT 3.12 SERIAL NUMBER MAC OS X.
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